Microfollicular thyroid adenoma and congenital goitrous hypothyroidism.
نویسندگان
چکیده
Three patients with congenital goitrous hypothyroidism are reported. They were treated with adequate thyroxine replacement and developed well defined microfollicular thyroid adenomas despite being euthyroid clinically and biochemically throughout their clinical course. Patients with congenital goitrous hypothyroidism appear to be at increased risk of developing thyroid adenoma in childhood despite the use of replacement thyroxine treatment in physiological doses.
منابع مشابه
Two novel mutations in the thyroid peroxidase gene with goitrous hypothyroidism.
We encountered a Japanese patient with goitrous hypothyroidism due to iodide organification defect in the thyroid gland. Sequence analysis identified two novel mutations (E378K in exon 8 and a heterozygous 10 base deletion of the intron 15-exon 16 boundary) in the thyroid peroxidase (TPO) gene. As individuals with goitrous hypothyroidism caused by TPO gene mutation develop thyroid cancer, regul...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 67 10 شماره
صفحات -
تاریخ انتشار 1992